Hereditary Angioedema (HAE) is a rare genetic disorder that causes sudden and recurrent swelling in different parts of the body, such as the hands, feet, face, intestinal tract, and airways. Unlike allergic reactions, HAE swelling is not caused by histamine and therefore does not respond to common allergy medications like antihistamines or corticosteroids. Instead, it’s usually due to a defect or deficiency in a blood protein called C1 inhibitor, which helps regulate inflammation. HAE attacks can be triggered by stress, illness, injury, dental work, or hormonal changes, but sometimes they occur without a clear cause. Treatment focuses on preventing attacks and treating them quickly when they happen. This can involve medications that replace or boost C1 inhibitor, block bradykinin (a swelling mediator), or help manage symptoms.

The symptoms caused by hereditary angioedema start in childhood and typically get worse during puberty. Without treatment, you may have an attack every week or two, with each episode lasting several days. The swelling caused by hereditary angioedema often appears for no apparent reason. At other times, something triggers the swelling, such as minor trauma or stress. The swollen areas are painful and usually red. You may also have tingling, or your skin could feel tight. Some people develop a non-itchy skin rash during flare-ups. If the swelling affects your gastrointestinal tract, you will have nausea, vomiting, and severe abdominal pain. Swelling in your mouth, tongue, throat, or airways makes it hard to breathe. This type of swelling can be life-threatening.

The team at Bellagio Family Medical, specializes in hereditary angioedema. They stay up-to-date with the current research and continuously look for new or upcoming treatment options. They also give you the ability to participate in research studies, if desired. They diagnose hereditary angioedema by evaluating your symptoms and running blood tests. The lab work finds biomarkers for hereditary angioedema and helps rule out other possible causes for your symptoms. Your provider prescribes medications that treat the swelling and prevent future attacks. They help you identify triggers and teach you how to self-treat at home when you have an attack.

If you experience any type of angioedema, call the office or schedule an appointment online today for a thorough examination and treatment to prevent future problems.